National-Scale Surveillance for New Variants of SARS-CoV-2


In a recent study researchers established and validated a strong approach for deducing public health-relevant epidemiological metrics, like relative variant abundance and variant-specific reproduction numbers, from wastewater (WW)-derived deep sequenced severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genomes in the context of a national-scale wastewater-based epidemiology (WBE) initiative.

SARS-CoV-2 surveillance is critical to discover variants with different epidemiological features. Individual instances can be sequenced using WBE, which is unbiased and complimentary. National WBE surveillance programs, on the other hand, have not been widely deployed, and data analysis remains difficult.

The findings show that WBE accurately reproduces epidemiological screening programs with a high spatiotemporal resolution, fewer samples, and less logistical effort. The virus aggregates in the WW represent the entire virus population, in contrast to the traditional method of aggregating consensus sequences of virus isolates from individual patients. This comprehensive view of the population presents opportunities and is likely to generate value for WBE.

In population genomics, it is well understood that a large sample rate benefits specific applications. The researchers aimed to integrate the two domains by using nucleotide diversity as a surrogate for introductions by tying the concept of nucleotide diversity to fundamental epidemiological metrics like prevalence and mobility. According to the findings, the absolute case number is imprinted in the observed nucleotide diversity. Mobility, on the other hand, had no influence. The dynamic distinctions in the appearance of Alpha and Delta viruses may hold the key to a better understanding and prediction of future virus population fluctuations.

In conclusion, this large-scale study highlights the utility of sequencing-based WW surveillance in the current SARS-CoV-2 pandemic, as well as its potential impact on improved worldwide surveillance of other infectious illnesses in the future.


Read more: https://www.tridhascholars.org/press-release/national-scale-surveillance-for-new-variants-of-sars-cov-2-in-wastewater.php

Source: https://www.tridhascholars.org/press-releases.php


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