COVID- 19 Observation for Fully Vaccinated and Boosted Patients
The researchers concluded that booster doses provided protection against severe COVID-19 symptoms and also observed that the number of patients requiring mechanical ventilation and use of vasopressors, as well as in-hospital mortality, were lower in the FV&B cohorts as compared to the UV cohorts, despite a higher risk for in-hospital mortality in the FV&B cohort.
When the researchers compared the FV&B patients who required ICU care to those who did not, it was observed that there may not have been enough time for the booster dose in these patients to be effective in preventing COVID-19 symptoms.
Decreased in-hospital mortality was observed in FV&B patients compared to UV patients, even though the former group was older and had a higher rate of pre-existing ESRD, higher proportion of immunocompromised state, and a higher proportion of immunocompromised state risk of in-hospital death in the FV&B cohort. It was observed that even among elderly patients with significant comorbidities, a booster dose might safeguard the patient against increased severity of symptoms.
Taken together, further investigations are required to understand the protection provided by booster vaccines and diagnose the risk factors in the FV&B population.
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